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<p><b>OBJECTIVE</b>To explore the clinical effects of percutaneous vertebroplasty(PVP)in the treatment of osteoporotic vertebral compression fractures complicated with intravertebral clefts.</p><p><b>METHODS</b>The clinical data of 176 patients with osteoporotic vertebral compression fractures underwent treatment from January 2013 to May 2016 were retrospectively analyzed. All the patients were treated by unilateral PVP procedure, 37 patients with intravertebral clefts. Seven cases were excluded according to the standard and 30 patients were internalized in the study. There were 14 males and 16 females, aged from 60 to 93 years old with an average of (77.73±9.33) years. The mean bone mineral density was (-3.16±0.48) SD (ranged from -2.3 to -4.1 SD). The Oswestry Disability Index(ODI), visual analogue scale (VAS) were analyzed before operation and 1 day, 3 months, 1 year after operation. The compression ratio of injured vertebrae was measured by X-ray before operation and 3 days, 3 months after operation.</p><p><b>RESULTS</b>All the operations were successful and all the patients were followed up more than 1 year. Postoperative at 1 d, 3 months, 1 year, VAS scores were obviously released (2.93±0.83, 2.07±0.58, 1.57±0.68, respectively) than preoperative 7.00±1.41(<0.01);and ODI scores were obviously improved (36.2±4.1, 22.9±6.7, 18.8±5.9, respectively) than preoperative 40.5±3.9(<0.01). Postoperative at 3 days, 3 months, vertebral height percent of injured vertebrae were (79.26±8.57)% , (77.68±8.96)% , respectively, which had obviously improvement compared to preoperative (72.00±12.14)% (<0.05).</p><p><b>CONCLUSIONS</b>PVP is an effective and reliable method in the treatment of osteoporotic vertebral compression fractures complicated with intravertebral clefts. It can effectively restore the height of the vertebral body, obviously improve the patient's pain and functional status.</p>
Subject(s)
Aged , Aged, 80 and over , Female , Humans , Male , Middle Aged , Fractures, Compression , General Surgery , Osteoporotic Fractures , General Surgery , Spinal Fractures , General Surgery , Treatment Outcome , VertebroplastyABSTRACT
Objective To evaluate the validity and reliability of simplified Chinese SF-36v2 questionnaire for assessment of life quality of people immigrating to high altitude at different time periods.Methods Two hundred and forty-eight Chinese young males,aged 16-36 years (mean 22.1 years),immigrating to an altitude of 4520m plateau for 0.3-10.8 years (mean 2.3 years),were selected by cluster sampling methods.The general demographic characteristics questionnaire and simplified Chinese SF-36v2 scale were investigated by self-administered questionnaire.Thirty-four subjects were randomly sampled and re-examined by questionnaire after 4 weeks.Results A total of 252 questionnaires were sent out,and a total of 248 valid questionnaires (98.4％) were collected.The scores of 8 scales in SF-36v2,including physical function (PF),role-physical (RP),bodily pain (BP),general health (GH),vitality (VT),social function (SF),role-emotional (RE) and mental health (MH),were 78.50 ± 15.34,63.30 ± 39.65,70.60 ± 17.69,56.40 ± 18.21,59.10 ± 18.18,85.70 ± 18.90,53.68 ± 41.65,59.35 ± 13.61.The floor effects were 0 except for RP (17.80％) and RE (27.92％) and the ceiling effects were 5.08％,40.11％,3.55％,0,2.54％,9.64％,31.47％,0.The split half reliability of SF-36v2 scale was 0.632-0.800,and the Cranbach's coefficient of α was 0.641-0.824,the test-retest reliability coefficient was 0.543-0.848.The success rate of set validity was 100％,and the total discriminant validity success rate was 95.36％.Factor analysis was used to extract 2 principal factors,which could explain 69.5％ of the total variance.Conclusion The simplified Chinese SF-36v2 scale has good internal consistency,reliability and validity,and it can be used to assess the quality of life in different periods.
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Accurate bracket placement is essential for efficient and ideal orthodontic treatment. Due to the extensive integration of computer technology into orthodontics, computer-aided positioning brackets and variable methods of indirect bonding develop rapidly, aiming to position the brackets more correctly and simply. Compared with direct bonding and indirect bonding based on plaster models, three-dimensional digital maxillofacial-dental models have the advantage of simulating the virtual bracket position and the whole treatment process, predicting the final treatment outcomes, consequently, allowing for more accurate bracket positioning and less chair time. Here we reviewed the recent development of bracket placement, direct and indirect positioning technique in orthodontics.
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<p><b>OBJECTIVE</b>To explore the expressions of P33ING1, P53 and their relationships with apoptosis in anal canal carcinoma (ACC).</p><p><b>METHODS</b>The expressions of P33ING1, P53 proteins were measured by immunohistochemistry method (SP method), and apoptosis was detected in 42 cases with ACC, 36 cases with anal canal adenoma (ACA) or anal canal papilloma (ACP), and 40 cases with paraanal inflammatory mass(PAIM).</p><p><b>RESULTS</b>The positive expression rates of P33ING1 and P53 proteins were 40.5% (17/42), 97.2% (35/36) and 97.5% (39/40), 50.0% (21/42), 22.2% (8/36) and 27.5% (11/40) respectively, and the average apoptosis indexes(AI) were (10.27+/- 1.23) per thousand, (42.75+/- 0.98) per thousand and (42.67+/- 1.04) per thousand respectively in ACC, ACA or ACP and PAIM. There were significant differences in the positive expression rates of P33ING1, P53 and apoptosis index between ACC and the other two groups respectively (P< 0.05). Among 21 cases of ACC with positive expression of P53 protein,there were 18 cases with P33ING1 negative expression.</p><p><b>CONCLUSIONS</b>P33ING1 expression decrease in ACC, which may play an important role in the carcinogenesis and progression of ACC. P33ING1 and P53 may have an synergistic effect of suppressing cell growth and accelerating cell apoptosis.</p>
Subject(s)
Adult , Aged , Aged, 80 and over , Female , Humans , Male , Middle Aged , Anus Neoplasms , Metabolism , Pathology , Apoptosis , Carcinoma , Metabolism , Pathology , Immunohistochemistry , Inhibitor of Growth Protein 1 , Intracellular Signaling Peptides and Proteins , Metabolism , Neoplasm Staging , Nuclear Proteins , Metabolism , Tumor Suppressor Protein p53 , Metabolism , Tumor Suppressor Proteins , MetabolismABSTRACT
Objective：To investigate the changes of calcitonin gene-related peptide immunoreactive (CGRP-IR)nerve fibers in rat dental pulps during acute inflammation. Methods： Rat acute pulpitis model was established by silk thread ligation and the change of CGRP-IR nerve fibers was observed with immunohistochemical method.Results： In radical pulp,the CGRP-IR nerve fibers became denser and more heavily stained；in the coronal pulp,the number of CGRP-IR nerve fibers decreased,but the background staining was heavier. Conclusion： During acute inflammation,the amount of CGRP increases in dental pulps, and is released into the surronding tissue in a large scale in the coronal region.
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Objective：To investigate the changes of calcitonin gene-related peptide immunoreactive (CGRP-IR)nerve fibers in rat dental pulps during acute inflammation. Methods： Rat acute pulpitis model was established by silk thread ligation and the change of CGRP-IR nerve fibers was observed with immunohistochemical method.Results： In radical pulp,the CGRP-IR nerve fibers became denser and more heavily stained；in the coronal pulp,the number of CGRP-IR nerve fibers decreased,but the background staining was heavier. Conclusion： During acute inflammation,the amount of CGRP increases in dental pulps, and is released into the surronding tissue in a large scale in the coronal region.